Two of the WordPress plugins I use on this site are Twitter Mentions as Comments and Growmap Anti Spambot Plugin. The first, TMAC, watches Twitter for any tweets that link to a post somewhere on this blog and submits those tweets as new comments on that particular post. GASP's job is to keep spammers from submitting spammy comments by placing a Javascript-driven checkbox in the comment form. A user must check the box to confirm they are not a spambot before submitting their comment.
Both of these plugins are great and work really well on their own.
However, when both plugins are in use and TMAC submits a comment, GASP inspects the comment to see if the checkbox has been marked, finds that it hasn't been, and silently rejects the comment. (Aside: the exception to this is if you are a logged-in user and you initiate a manual TMAC check, any new tweets will successfully pass through GASP).